Κεντρική σελίδα

Group of Cancer Immunology (GCIM)


Ioannou K, Samara P, Livaniou E, Derhovanessian E, Tsitsilonis OE. Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy. Cancer Immunol. Immunother. 2012, in press.

Argyropoulou A, Samara P, Tsitsilonis O, Skaltsa H. Polar Constituents of Marrubium thessalum Boiss. & Heldr. (Lamiaceae) and their cytotoxic/cytostatic activity. Phytother. Res. 2012, in press.



Ziogas AC, Gavalas NG, Tsiatas M, Tsitsilonis O, Politi E, Terpos E, Rodolakis A, Vlahos G, Thomakos N, Haidopoulos D, Antsaklis A, Dimopoulos MA, Bamias A. VEGF directly suppresses activation of T cells from ovarian cancer patients and healthy individuals via VEGF receptor Type 2. Int. J. Cancer 2011, in press.

Christodoulou A, Kostakis IK, Kouroufalos V, Pouli N, Marakos P, Trougakos IP, Tsitsilonis OE. Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles. Bioorg. Med. Chem. Lett. 21:3110-2, 2011.



Ioannou K, Samara P, Kavrochorianou N, Bega C, Thyfronitis G, Haralambous S, Tsitsilonis O. The C-terminal decapeptide of prothymosin α induces a Th1-type immune response in vitro and retards tumor growth in vivo. Cytokine 52:47, 2010.

Pitychoutis PM, Tsitsilonis OE, Papadopoulou-Daifoti Z. Antidepressant pharmacotherapy: focus on sex differences in neuroimmunopharmacological crossroads. Future Neurol. 5: 581-96, 2010.



Skopeliti M, Iconomidou V, Derhovanessian E, Pawelec G, Voelter W, Kalbacher H, Hamodrakas SJ, Tsitsilonis OE. Prothymosin alpha’s immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions via dendritic cell maturation adopting beta-sheet conformation in a sequence specific manner. Mol. Immunol. 46: 784-92, 2009.

Georgaki S, Skopeliti M, Tsiatas M, Nicolaou KA, Ioannou K, Husband A, Bamias A, Dimopoulos MA, Constantinou AI, Tsitsilonis OE. Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo. J. Cell. Mol. Med. 13: 3929-38, 2009

Pitychoutis PM, Griva E, Ioannou K, Tsitsilonis OE, Papadopoulou-Daifoti Z. Chronic antidepressant treatment exerts sexually dimorphic immunomodulatory effects in an experimental model of major depression: do females lack an advantage?. Int. J. Neurophychopharmacol. 12: 1157-63, 2009.



Bamias A, Koutsoukou V, Terpos E, Tsiatas ML, Liakos C, Tsitsilonis O, Rodolakis A, Voulgaris Z, Vlahos G, Papageorgiou T, Papatheodoridis G, Archimandritis A, Antsaklis A, Dimopoulos MA. Correlation of NK T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFalpha in ascites from advanced ovarian cancer: Association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapy. Gynecol. Oncol. 108: 421-7, 2008.



Skopeliti M, Kratzer U, Altenberend F, Panayotou G, Kalbacher H, Stevanovic S, Voelter W, Tsitsilonis OE. Proteomic exploitation on prothymosin α-induced monocuclear cell activation. Proteomics 7:1814-24, 2007.

Bamias A, Tsiatas M, Kafantari E, Liakos C, Rodolakis A, Voulgaris Z, Vlahos G, Papageorgiou T, Tsitsilonis O, Bamia C, Papatheodoridis G, Politi E, Archimandritis A, Antsaklis A, Dimopoulos MA. Significant differences of lymphocytes isolated from ascites of patients with ovarian cancer compared to blood and tumor lymphocytes. Association of CD3+CD56+ cells with platinum resistance. Gynecol. Oncol. 106: 75-81, 2007.

Klimentzou P, Beck A, Varvarigou A, Tsitsilonis O, Voelter W, Pirmettis I, Papadopoulos M, Livaniou E, Zikos C. Solid-phase synthesis of a peptide derivative of thymosin α1 and initial studies on its (99m)Tc-radiolabelling. Chem. Biol. Drug Des. 70: 40-6, 2007.

Valakos ED, Kourkouli A, Skopeliti M, Pafilis P, Poulakakis N, Voutsas IF, Lymberakis P, Simou C, Voelter W, Tsitsilonis OE. Combining immunological and molecular data to assess phylogenetic relations of some Greek Podarcis species. Comp. Biochem. Physiol. B 147: 1-10, 2007.

Karioti A, Skopeliti M, Tsitsilonis O, Heilmann J, Skaltsa H. Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. Phytochemistry 68: 1587-94, 2007.



Skopeliti M, Voutsas IF, Klimentzou P, Tsiatas ML, Beck A, Bamias A, Moraki M, Livaniou E, Neagu M, Voelter W, Tsitsilonis OE. The immunologically active site of prothymosin α is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients. Cancer Immunol. Immunother. 55:1247-57, 2006.

Klimentzou P, Paravatou-Petsotas M, Zikos C, Beck A, Skopeliti M, Czarnecki J, Tsitsilonis O, Voelter W, Livaniou E, Evangelatos GP. Development and immunochemical evaluation of antibodies Y for the poorly immunogenic polypeptide prothymosin alpha. Peptides 27:183-93, 2006.



Voelter W, Wacker R, Tsitsilonis R, Stoeva S, Franz M. Structure and function of chitin-binding Mistletoe lectins. In: Fortschritte in der Misteltherapie: Actueller Stand der Forschung und klinische Anwendung, R. Scheer, R. Bauer, H. Becker, V. Fintelmann, F.H. Kemper, H. Schilcher (ed), pp. 55-68, KVC Verlag, Essen, 2005.

Franz M, Vollmer S, Wacker R, Jaeger S, Scheer R, Stoeva S, Lehmann R, Tsitsilonis R, Voelter W. Isolation and quantification of the chitin-binding Mistletoe lectins (cbMLs) from the Mistletoe extracts and the validation of this method. In: Fortschritte in der Misteltherapie: Actueller Stand der Forschung und klinische Anwendung, R. Scheer, R. Bauer, H. Becker, V. Fintelmann, F.H. Kemper, H. Schilcher (ed), pp. 69-81, KVC Verlag, Essen, 2005.



Tsavaris NB, Katsoulas HL, Kosmas C, Papalambros E, Gouveris P, Papantoniou N, Rokana S, Kosmas N, Skopeliti M, Tsitsilonis OE. The effect of edrecolomab (Mo17-1A) or fluorouracil-based chemotherapy on specific immune parameters in patients with colorectal cancer. A comparative study. Oncology 67:403-10, 2004.

Tsitsilonis OE, Thrasyvoulides A, Balafas A, Voutsas JF, Papamichail M, Lymberi P. Serological detection of hepatitis B viral infection by a panel of solid-phase enzyme-linked immunosorbent assays (ELISA). J. Pharm. Biomed. Anal. 38:811-22, 2004.

Voelter W, Wacker R, Stoeva S, Tsitsilonis R, Betzel C. Mistletoe lectins, structure and function. In: Frontiers in Natural Product Chemistry, Atta-ur-Rahman, M.I. Choudhary, K.M. Khan (ed), Vol. 1, pp.149-62, Bentham Science Publishers Ltd., The Netherlands, 2004.



Tsitsilonis OE, Tsavaris NB, Kosmas C, Gouveris P, Papalambros E. Immune changes in patients with colorectal cancer treated by adjuvant therapy with monoclonal antibody 17-1A. A pilot study. J. Chemother. 15:387-93, 2003.



Baxevanis CN, Gritzapis AD, Tsitsilonis OE, Katsoulas HL, Papamichail M. HER-2/neu-derived peptide epitopes are also recognized by cytotoxic CD3+CD56+ (NKT) lymphocytes. Int. J. Cancer 98:864-72, 2002.

Tsitsilonis OE, Stoeva S, Echner H, Balafas A, Margomenou L, Katsoulas HL, Troy DJ, Voelter W, Papamichail M, Lymberi P. A skeletal muscle troponin T ELISA based on the use of an antibody against the soluble troponin T (16-31) fragment. J. Immunol. Meth. 268:141-8, 2002.



Baxevanis CN, Voutsas IF, Tsitsilonis OE, Gritzapis AD, Soteriadou R, Papamichail M. Tumor specific CD4+ T lymphocytes from cancer patients are required for optimal induction of cytotoxic T cells against the autologous tumor. J. Immunol. 164: 3902-12, 2000.

Baxevanis CN, Voutsas IF, Tsitsilonis OE, Tsiatas ML, Gritzapis AD, Papamichail M. Compromised anti-tumor responses in tumor necrosis factor-α knockout mice. Eur. J. Immunol. 30: 1957-66, 2000.

Voelter W, Stoeva S, Echner H, Beck A, Schutz J, Lehmann R, Haring HU, Schleicher E, Mullen AM, Casserly U, Troy DJ, Tsitsilonis OE, Lymberi P, Baxevanis CN, Papamichail M. Analytical tools for rapid, sensitive, quantitative identification of potential meat quality markers. J. Prakt. Chem. 342: 179-91, 2000.